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Hypovolemia and carbohydrate deficiency lead to increased glucagon secretion, reduced endogenous insulin secretion, and elevated glucagon-to-insulin ratio, and subsequently trigger lipolysis and hepatic ketogenesis in the setting of euglycemia

| 2022 | International Journal of Molecular Sciences)

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As expected, since MTT and CTG assays measure cellular metabolism, the CC 50 values of both compounds were somehow lower in the various cell types as compared to growth curve assessment