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Blood sugar stability affects brain function directly

Mitochondrial damage and subsequent dysfunction not only reduce energy production but also increases ROS generation, creating a self-perpetuating cycle of oxidative stress and metabolic impairment

Fatigue: Despite increased activity, individuals may feel tired and weak

However, if you have lost significant weight while on tirzepatide, your body composition has changed permanently, at least until weight regain occurs, and your levothyroxine dose should reflect your current weight rather than your pre-treatment weight

Pettitt DJ, Ospina P, Kolaczynski JW, et al