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A meaningful share of weight lost on GLP-1 medications can come from lean mass rather than fat, with reported proportions varying across study populations

For doseresponse measurements, cells were treated with varying amounts of the respective molecule for the time indicated

Preclinical studies have explored its potential effects on the gastrointestinal tract, muscles, ligaments, tendons, and nerves

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This blunted adaptation means that higher or more prolonged stimulus (longer training periods, optimal nutrition) is often needed to achieve gains in elders