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The degree of appetite suppression varies from person to person and often increases as doses are adjusted over time

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117 47 29959-29967 6X1A 2020 Nov 5 Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists

Clinical studies have shown that tirzepatide: Significantly reduces hemoglobin A1C levels compared to placebo Promotes weight loss in a dose-dependent manner May have potential benefits for non-alcoholic fatty liver disease (NAFLD) patients Tirzepatide is typically administered as follows: Once-weekly subcutaneous injection Available in various strengths (e.g., 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg) Dose is usually titrated over time to reach the target dose Common side effects may include: Nausea Diarrhea Decreased appetite Vomiting Constipation Abdominal pain Tirzepatide should be used with caution in patients with: History of pancreatitis Severe gastrointestinal disease Diabetic retinopathy Pregnancy: Tirzepatide should not be used during pregnancy unless the potential benefit justifies the potential risk to the fetus