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In Group A, only a slight decrease in the percentage of inhibition (from 80.93% to 62.30%) was found even at the lowest AX concentration (0.01 mM)

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Further investigations are needed to determine the value of H3K27me3 as a predictive marker for establishing sensitivity to epigenetic-based therapies (EZH2 inhibitors, BRD4 targeted therapies) in tumors such as malignant peripheral nerve sheath tumor and melanoma

doi: 10.3389/fphar.2017.00279 38 FerrisC.TenneyJ

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