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Over eighty ADs exist, with the majority of these typically characterised by the immune systems inability to distinguish between self-components and those which pose a threat to host health (Smyth 2017)

Model analysis Selection of parameters for estimation The methodology to select parameters for estimation involves first conducting local sensitivity analysis (LSA) to obtain a set of important parameters, and then determining from this set of parameters which are identifiable, that is for which parameters a value can be identified from the data, taking into account the model structure

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