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GLP-1 receptor agonism is also achieved by inhibitors of dipeptidyl peptidase-4 (DPP-4), which prevent the inactivation of GLP-1 and glucose-dependent insulinotropic polypeptide (GIP), thereby prolonging their raised levels after meal ingestion

But interest is growing in their effects beyond metabolismparticularly their potential influence on the brain and risk of dementia

As with the other peptides weve discussed so far, these effects are more common upon the initiation of therapy

VanuytselTvan WanrooySVanheelHVanormelingenCVerschuerenSHoubenEet al

Conditions such as lupus, Guillain-Barre syndrome, rheumatoid arthritis, and Sjorgens syndrome can also result in nerve damage