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The SELECT trial showed that semaglutide 2.4 mg (Wegovy) reduces cardiovascular risk in adults with established cardiovascular disease and either overweight or obesity, leading to an FDA-approved indication for reducing cardiovascular risk in this population

Is it safe to lose more than 2 pounds per week on semaglutide

Insufficient protein during rapid weight loss leads to muscle wasting, which worsens fatigue, reduces metabolic rate, and produces the "skinny fat" outcome nobody wants

Achieving and sustaining a healthier weight and improving insulin sensitivity with GLP-1 RAs may also improve skin health. GIP and GLP-1 Dual Agonists in Dermatology GLP-1 RAs offer numerous advantages, but tirzepatide offers added benefits as a dual agonist

10.7326/M13-1725 [EL 1