The key is getting back on your providers recommended schedule rather than giving up on it entirely
Signs of dehydration to watch for: Dark urine Dry mouth Dizziness Feeling lightheaded Increase your fluid intake during dose escalation if you are experiencing digestive symptoms
For short-half-life peptides that fail the oral feasibility test, long-acting injectable formulations may be the most realistic pathway to reduced treatment burden (Table 4)
We offer a range of assays and in vivo models to assess the therapeutic potential of novel drugs to treat obesity: Rodent models DIO and weight gain in mice and rats Most commercially available genetic models Drug-induced weight gain (Olanzapine, Pioglitazone) Acute Studies Food intake assessment (fed, fasted, dark-phase induced, palatable diet models) Behavioural profiling Gastric emptying Glucose and insulin tolerance (OGTT, IPGTT, IVGTT, ITT) Energy expenditure (by indirect calorimetry) Chronic Studies Chronic dosing or subcutaneous infusion (up to 12 weeks) Body weight, food and water intake Pair-feeding and weight-matching paradigms Body composition (validated scanning techniques or full chemical carcass analysis) Plasma, urine and liver metabolic parameters and biomarkers Glucose and insulin tolerance (OGTT, IPGTT, IVGTT, ITT) Energy expenditure (by indirect calorimetry) Faecal energy content We offer full experimental design consultation, tailoring your study to your exact requirements
Ritchie, M
