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Notably, tumor angiogenesis plays a crucial role in the occurrence of drug resistance in breast cancer

Furthermore, this population had high utilization of medications known to improve outcomes (for example, 93% were on statins, 92% were on Angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers, among others)

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If gastrointestinal symptoms significantly impair quality of life or prevent medication adherence despite conservative management, healthcare providers may consider dose adjustment, alternative agents with potentially different side effect profiles, or referral to a gastroenterologist for specialized evaluation