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A patient with a 'fast responder' genotype variant might still lose weight slowly if baseline metabolic inflammation is minimal or lifestyle adherence is suboptimal
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Biochem Pharmacol (2019) 168:193203
Semaglutide works through three simultaneous pathways
In SURMOUNT 4, all participants received the maximum tolerated dose of tirzepatide for 36 weeks and were then randomized 1:1 to continue tirzepatide or receive placebo until 88 weeks
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