In summary, B12 IV dosing needs a personalized approach
Then what we do in humans is we kind of rely on our best proxy biomarkers that we think reflect the systems that drive aging and we can measure those things over time and sort of estimate what we think is the effective this dietary change or that dietary change or this lifestyle change or that drug change on those things
Pheomelanin Yellow/red pigment Weak UV absorption Generates free radicals when UV-exposed Dominant in pale, red-haired, or Northern-European skin types Strongly linked to high skin cancer risk Research confirms this dichotomy: eumelanin is UV-absorbent and protective, while pheomelanin acts as a photosensitizer that can amplify UV damage
Transient overexpression of wild-type (WT)4 and mutant rab3a proteins inhibited exocytosis in bovine adrenal chromaffin cells and the PC12 neuroendocrine cell line (21,22), while inhibition of rab3b expression by antisense Abbretjiations used in this paper: WT, wdd-type
Its well-established roles are antioxidant defense, hepatic detoxification, and immune support
