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No lethal dose was reached in preclinical toxicology studies, and no significant adverse effects have been reported in published research

When free radicals accumulate faster than the body can neutralize them, they can: Accelerate Cellular Aging: Oxidative damage to DNA, proteins, and cell membranes can contribute to the aging process at a cellular level

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When cytosolic Ca 2+ levels are increased, mitochondria become a high-capacity storage for these ions contributing to the normalization of Ca 2+ concentration [89]