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Aspirin treatment significantly increased intracellular glutamine levels in HCT116 cells, regardless of oxygen availability and PIK3CA mutation status

DeNicola GM, Karreth FA, Humpton TJ, Gopinathan A, Wei C, Frese K, Mangal D, Yu KH, Yeo CJ, Calhoun ES, Scrimieri F, Winter JM, Hruban RH, Iacobuzio-Donahue C, Kern SE, Blair IA, Tuveson DA

These metabolites also serve as critical signaling molecules in host-microbe cross-talk, preserving the integrity of the intestinal mucosal barrier and supporting the maintenance of intestinal and systemic homeostasis (89)

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