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Li et al ., 2004)

In animal studies, GLP-1s caused thyroid tumors in rodents

Establish a collagen-induced arthritis (CIA) rat model, that is, rheumatoid arthritis (RA ) model

First, the small cohort (16 eyes randomized, 15 analyzable) was adequately powered for the primary TNF- endpoint but may be underpowered for secondary outcomes, thereby limiting statistical reliability for these measures