The grades of the coffee enema with PEG group were significantly better than those of the PEG-only group in the mid (B) and distal (C) small bowel segments and the terminal ileum (D) (p = 0.04, p = 0.001, and p = 0.007, respectively)
Medgyesi B, Dajnoki Z, Bke G, et al
Clinical translation requires human CSF pharmacokinetic assays to prove BBB bypass, a rigorous dose-escalation Phase I trial to establish a safe human NOAEL for chronic dosing, and an RCT utilizing precise neurocognitive testing (e.g., MoCA) to confirm that murine transcriptomic shifts yield functional neuroprotection in humans
Inflammation is associated with decreased functional connectivity within corticostriatal reward circuitry in depression
[DOI] [PMC free article] [PubMed] [Google Scholar] 129.Lutchmansingh F.K., Hsu J.W., Bennett F.I., Badaloo A.V., McFarlane-Anderson N., Gordon-Strachan G.M., Wright-Pascoe R.A., Jahoor F., Boyne M.S