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Seiwerth and colleagues (Inflammopharmacology, 1999) documented effects on angiogenic growth factor pathway signalling, and subsequent work has expanded characterisation to include VEGF receptor 2 upregulation, endothelial cell migration in capillary-formation assays, and improved healing in ischemia-reperfusion preparations

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And the treatment depends entirely on the reason

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Currently, its FDA-approved only for treating methemoglobinemia, although doctors also use it off-label for other conditions