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The supernatant was collected and screened for crypts by microscopy

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Hyaluronic Acid acts as a "water highway," carrying the peptides deep into the dermis where they can be most effective

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Following washing in PBS with 0.1% saponin and 0.1% Tween 20, secondary antibody conjugated with goat anti-Mouse IgG Alexa Fluor 488 and Phalloidin conjugated with Alexa Fluor 594 were incubated for 2 h at room temperature