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This stepwise approach minimizes gastrointestinal side effects but means that full appetite-suppressing effects may not manifest until patients reach higher doses, often at 1.7 mg or 2.4 mg weekly for weight management indications

Compounded versions of semaglutide and tirzepatide present patient safety and efficacy concerns: Dosing errors, variable product quality and a lack of FDA approval for compounded formulations have led to FDA regulatory warnings

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