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Some experts suggest an induction-maintenance model : initiating treatment with subcutaneous injections for rapid initial weight loss, followed by long-term oral maintenance

The serine/glycine synthesis pathway branches from glycolysis via the glycolytic intermediate 3-phospho-glycerate, which can be converted into serine via three enzymatic reactions catalyzed by PHGDH, PSAT1, and PSPH, followed by the reversible interconversion of serine into glycine by SHMT1/2 (Figure 1)(2)

Eating smaller meals, staying hydrated and avoiding heavy or greasy foods may help reduce these effects