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In terms of sphingolipids metabolism, the rs267734 gene variant of Ceramide synthases 2 (CerS2) in patients with DKD resulted in increased proteinuria (108), and polymorphisms in the Sphingosine-1-phosphate lyase 1(SGPL1) gene encoding S1P lyase 1 were associated with reduced enzymatic activity of S1P lyase 1 and the development of nephropathy

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Neuroprotective Effects : Emerging research suggests it can support nerve healing and provide protective benefits for the brain

Patients treated with 6-gingerol did not show any toxicity during a phase II randomized double-blind placebo-controlled study [275]

Nitric oxide and mitochondrial biogenesis: a key to long-term regulation of cellular metabolism