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Without sufficient B12, one's energy levels can plummet , leading to fatigue and lethargy

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Relative contraindications requiring careful consideration and enhanced medical supervision include history of pancreatitis, severe gastrointestinal disease including gastroparesis, diabetic retinopathy (requires ophthalmologic monitoring during therapy), severe kidney disease, history of suicidal ideation or severe depression, gallbladder disease or history of cholecystitis, and age under 18 years

It is associated with supporting overall skin clarity and influencing melanin production gradually, which may contribute to a more even-looking complexion over time

Therefore, regular ophthalmologic evaluations are recommended for patients initiating GLP-1 therapy