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This suggests that the key feature that controls RSS specificity is the enhanced nucleophilicity of the attacking (N-terminal) Cys, which is distinct from persulfide sensors of the ArsR family, e.g., SqrR, which Cys nucleophilicity is lower (Section 3.2.2.4)
The most effective way to minimize side effects is slow dose escalation under medical supervision
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The same goes for many of our other research compounds, from TB 500 to more complex stacks like the Wolverine Peptide Stack
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