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Dosing Phases & Cycling The KLOW research protocol is built as three descending-frequency phases plus an on/off cycle

History [edit] Descriptions of deficiency effects [edit] Between 1849 and 1887, Thomas Addison described a case of pernicious anemia, William Osler and William Gardner first described a case of neuropathy, Hayem described large red cells in the peripheral blood in this condition, which he called "giant blood corpuscles" (now called macrocytes), Paul Ehrlich identified megaloblasts in the bone marrow, and Ludwig Lichtheim described a case of myelopathy

Only clinical study designs (S)randomised controlled trials (RCTs), non-RCTs, cohort, or case-control studieswere included