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Their study, conducted in a rat model of uremia, demonstrated that the encapsulated bacteria effectively reduced elevated plasma urea levels without systemic exposure to the engineered cells, presenting a promising strategy for urea reduction in CKD

(1) Bailes J, Soloviev M

Evidence for operation of the direct zinc ligand exchange mechanism for trafficking, transport, and reactivity of zinc in mammalian cells

These investigations have evaluated biochemical, electrophysiological, and symptom-related endpoints to explore ALAs redox-associated activity in specific study populations