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Omega-3 Polyunsaturated Fatty Acids (Omega-3 or n-3 PUFAs) , eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA), are broad-spectrum anti-inflammatory compounds that modulate several pathways of inflammation including leukocyte chemotaxis, adhesion molecule expression, and leukocyte-endothelial adhesive interactions, inflammatory cytokine synthesis and T cell reactivity 708
In a study on hepatocellular carcinoma (HCC), Zip2 and Zip9 were upregulated in M2-polarized macrophages, while Zip9 was slightly downregulated in M1-polarized macrophages
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