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NNMT (nicotinamide N-methyltransferase) is an enzyme found in fat cells and other tissues that can become overactive in certain metabolic conditions

Then, they do weekly injections for a month

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The investigators interpreted the effects as direct pharmacological validation of the NNMT-knockdown phenotype reported earlier in genetic models

The finding of Ileibacterium as the most abundant cecal microbiome genus in every experimental group is relatively novel and may reflect experimental factors such as diet, housing conditions, and mouse strain