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Its a modifier on top of the main calculation, not a separate major factor

13% of the participants treated with the combined compound ended up discontinuing the trial, while 10% of the participants treated with semaglutide discontinued, however, none of the participants treated with cagrilintide discontinued their treatment plan indicating that cagrilintide was the most well tolerated by the study participants [2]

It entails: Consultation: An evaluation of your skin type, medical history and desired outcome of treatment

In the EU and other regions, it faces similar restrictions