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B12 supplementation with semaglutide and B12 with tirzepatide are common pairings

Stimulates insulin secretion by the pancreas

Better Metabolic Flexibility and Mitochondrial Health Metabolic flexibilitythe ability to switch between burning carbohydrates and fatsis impaired in obesity and insulin resistance

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Adjustments can include slowing the titration schedule, increasing the pyridoxine component, adding ondansetron for breakthrough nausea, or switching to a different GLP-1 medication if semaglutide fundamentally does not agree with your system