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Unlike differentiated cancer cells, which exhibit a relatively fixed metabolic phenotype, CSCs demonstrate a remarkable ability to switch between glycolysis and OXPHOS depending on environmental conditions and therapeutic pressure

pubmed.ncbi.nlm.nih.gov/28490897/ Watanabe F et al

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Therefore, further exploration of glutamine metabolism in tumors is essential for understanding the pathogenesis of cancer and for developing new metabolically targeted therapies

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