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Hyperpigmentation was observed when this compound got oxidized and inactivated by factors such as heat, radiation and inflammation with consequent loss of the inhibitory effect on tyrosinase

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Aspirin, zinc chloride, vitamin D, sorafenib, selenium, sunitinib, and stannsoporfin were identified as HMOX1-targeted drugs in the DGIdb dataset, whereas NADH (DB00157) and vitamin E (DB00163) were found in the DrugBank dataset which was shown in Table 2

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