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Insulin sensitivity, assessed by the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), improved with the administration of CT-388, particularly in the highest dosed cohort

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The use of whole-body Glp-1r / mice and GLP-1R agonists such as EX-4 have helped establish many of the physiological roles of the GLP-1R, but determining the whole-body expression pattern of GLP-1R protein is needed to understand specific actions of GLP-1 on various organ systems

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A considerable GLP-1Rpositive presence was also noted in the hindbrain, including the AP and the external cuneate nucleus