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Side effects can happen, particularly GI side effects like nausea, diarrhea, and constipation

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The clinical significance of this effect is not fully characterized, but some providers recommend that women on oral contraceptives switch to a non-oral method (patch, ring, IUD, implant) when starting GLP-1 therapy, or use backup contraception during the titration period

Investigated in laboratory settings involving pigment-related cellular pathways