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Instead of acting locally on the skin, its introduced systemically, usually in small doses injected under the skin

joe bernstein So this came up in a past interview

the one or more hepatocyte growth factor mimics has or have a general structural formula R] is one of an N-acyl group, a substituted or unsubstituted phenyl, a norleucine group, and an amino acid selected from tyrosine, phenylalanine, aspartic acid, arginine, isoleucine, serine, histidine, glycine, cysteine, methionine, tryptophan, lysine norvaline, ornithine, and s-benzyl cysteine

IGF-1 LR3 has been shown to influence metabolic processes, leading to increased fat loss and better nutrient partitioning

Understanding both PK and PD, helps estimate the exposure levels likely to be efficacious and the exposure levels that might induce side effects in humans