This is normal and typically subsides within minutes
any alterations are secondary to metabolic improvements and weight reduction
Another issue with clinical translation is patient genetic variation in the expression of NAD + synthesis genes, or lifestyle conditions changes, including exercise regimens, that would influence the effectiveness of interventions
Practical measures that may help reduce GI discomfort include: Eating smaller, more frequent meals rather than large portions, to reduce the burden on a stomach that is already emptying more slowly Avoiding high-fat or heavily processed foods , which can exacerbate nausea and slow digestion further Staying well hydrated , particularly if diarrhoea is present, to prevent dehydration Eating slowly and chewing food thoroughly to ease the digestive process Avoiding lying down immediately after eating , which can worsen nausea For constipation specifically, increasing dietary fibre intake (fruits, vegetables, and wholegrains) and maintaining adequate fluid intake are first-line approaches consistent with NHS dietary guidance
Tracking your cycle and communicating with your provider can help manage any irregularities