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Based on millennia of adaptations to the plateaus extreme conditionscharacterized by hypobaric hypoxia (HH), overload of UV radiation, and drastic diurnal temperature fluctuationsthis indigenous medical system articulates unique pathophysiological interpretations and interventional strategies that diverge from, yet complement, contemporary biomedical approaches ( Contemporary scientific investigations have validated the fact that traditional botanical drugs and their formulations derived from TCM and TM possess distinctive benefits for preventing and treating HACE by modulating mechanisms such as anti-hypoxia, hypoxic pulmonary hypertension reduction, angiogenesis and vasoconstriction inhibition, decreased blood-flow resistance, reduced cell permeability, inflammatory response alleviation, and anti-oxidative stress ( Rhodiola and Saussurea involucrata , have demonstrated good anti-hypoxia and neuroprotective effects ( Despite the important role of modern medicine in the emergent treatment of HACE, TCM and TM offer new ideas and methods for the prevention and treatment of this condition, with their multi-targeted and holistic regulatory advantages