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Regulatory: Not evaluated by the FDA

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As one of the most extensively studied GLP-1 receptor agonists, Semaglutide has been the subject of multiple large-scale clinical trial programs (SUSTAIN, STEP, SELECT, PIONEER) investigating its effects on glucose homeostasis, body weight regulation, and cardiovascular outcomes

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In addition, the expression levels of several genes associated with apoptosis were upregulated in the adipocyte-rich fraction isolated from eWAT or sWAT of intermittently fasted (HFD-IF) in comparison to ad libitum fed (HFD-AL) obese mice, while markers of senescence ( p16 ) and DNA-damage ( Parp1 ) were not changed (Fig