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For each trial, the risk of bias was judged using the following five domains: (1) bias arising from the randomization process, (2) bias due to deviations from intended interventions, (3) bias due to missing outcome data, (4) bias in measurement of the outcome, and (5) bias in selection of the reported result, and then derived an overall risk-of-bias judgment

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Glucose-mediated G6PD inhibition reduced insulin secretion from -islets and induced -cells apoptosis, with overexpression of G6PD rescuing high glucose mediated dysfunction [34]

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Once reconstituted, the peptide solution should be stored at 28C (standard refrigeration)