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GPx1 deficiency may also (partially) protect liver hepatocytes against acetaminophen-mediated toxicity by mechanisms that decrease protein nitration and cell death, whereas GPx1 overexpressing mice are more sensitive to acetaminophen-mediated hepatotoxicity, in part due to an exhaustion of GSH [175]

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The effect exerted by one atom of the toxic metal must thus be able to yield a multiplicative effect, such as that corresponding to the inhibition or inactivation of key enzymes that contain thiol groups as part of functional or regulatory mechanism

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While it is a more natural choice, it should be used sparingly by GLP-1 users

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