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When tirzepatide binds to GLP-1 and GIP receptors, it sends coordinated signals that can reduce appetite, slow gastric emptying and improve insulin responseworking together to enhance overall metabolic outcomes

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Evidence supports an indirect relationship mediated by weight reduction, improved insulin sensitivity, and normalization of hormonal and inflammatory pathways

Now a growing number of researchers, payers, and providers are exploring deliberate deprescription, which aims to taper some patients off their medication after they have taken it for a certain amount of time or lost a certain amount of weight