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While these numbers show effectiveness, they also suggest that expectations should be managed, especially given the significant financial investment

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*Correspondence: Theerthankar Das, [email protected]

Optimization of a novel series of fused -homophenylalanine DPP-4 inhibitors was reported in detail by Jiang et al., leading to the development of -homophenylalanine analogs containing pyrrolidin-2-yl methyl amides (123)