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These endogenous gut hormones act on the central nervous system either via the circulation through areas deficient in the bloodbrain barrier, such as the median eminence of the hypothalamus and the area postrema [5] or via receptors of vagal afferents, together with stretch receptors and nutrient chemoreceptors [6]

Exploratory objectives To explore changes in brain functional activity and connectivity in addiction-related regions using fMRI, and to investigate potential associations between neural measures, nicotine dependence, and metabolic changes

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