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doi: 10.1016/j.biopha.2024.117079

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Its bone-targeting property has important clinical and safety implications, and has shown significant efficacy and safety in alleviating bone metastasis pain caused by prostate, breast, and other malignant tumors

Semaglutide, in particular, has shown promising results in reducing cardiovascular events in patients with type 2 diabetes, making it a valuable tool for long-term health management

Response: We appreciate commenters for the suggestion on the alternative ASM risk levels that we considered, including suggestions on a glidepath to more substantial levels of risk while ASM participants are becoming accustomed to the model's requirements