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In contrast to the direct supplementation of L-arginine, which is subject to significant hepatic metabolism, CIT circumvents first-pass degradation and represents a more effective approach for enhancing systemic L-arginine levels and the bioavailability of NO

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Within-pair titration analysis Jastreboff 2023 supplementary tables S4 + S5, Figure 1A trajectory data, Figure S9 panel A AE temporal data

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