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Under in vitro conditions, disruption of Syns tertiary ensemblesthrough charge neutralization (acidic pH or Ca 2+ addition), C-terminal truncation, or Syn-S129p could expose the hydrophobic (NAC) region and transform it into a metastable, reactive state 15,68

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James SJ, Melnyk S, Jernigan S, Cleves MA, Halsted CH, Wong DH, Cutler P, Bock K et al (2006) Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism

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