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The role of leptin in anorexia nervosa: clinical implications

Without adequate closing pressure from the lower esophageal sphincter, stomach acid inevitably escapes into the esophagus regardless of how effectively medications reduce overall acid production

If hyperpigmentation occurs, it typically resolves within weeks to months after treatment stops

The most common retatrutide side effects are nausea (28%), diarrhea (24%), constipation (21%), and vomiting (17%), with symptoms peaking around weeks 6-8 before substantially improving by week 12