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In addition, increasing TFAM levels enhanced mitochondrial DNA transcription and replication, aiding in the recovery of mitochondrial function, while boosting GPX4 levels directly reduced LPO buildup, thereby preventing ferroptosis
For horses, these benefits can translate into faster healing of tendons, ligaments, and muscles, which is crucial for performance and overall health
It promotes the healing of stomach and intestinal lining, maintaining gut health and function
In contrast, loss of ACSL4 or overexpression of GPX4 can prevent ferroptosis in T cells [89,90,91,92]
