how were glp 1 agonists discovered

how were glp 1 agonists discovered GLP-1 Receptor Agonists: From Diabetes Drugs to a New Era of Metabolic & Systemic Medicine Frontiers | GLP-1 receptor agonists:

Name: how were glp 1 agonists discovered GLP-1 Receptor Agonists: From Diabetes Drugs to a New Era of Metabolic & Systemic Medicine Frontiers | GLP-1 receptor agonists:
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Experimental mice in cohorts of 3-6 were infected ip on day 0 with between 1 10 6 and 1 10 7 iRBC harvested from donor mice

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The whole liver was removed, and the same part of the liver tissues were taken and fixed in 4% paraformaldehyde solution, and the rest of the liver tissues were stored in a 80C refrigerator