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falciparum exists in an open confirmation, the incorporation of EXP2 into membranes would need to be regulated to permit nutrient exchange only at the PVM

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The proportion of an oral dose that undergoes Phase I vs Phase II metabolism depends on enzyme expression levels, which vary by age, sex, liver health, and concurrent substrate competition

Methyl B12 then give up this methyl group to join with homocysteine to form methionine

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