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Some clinical observations suggest that injecting in the thigh may result in slightly fewer gastrointestinal side effects for certain individuals, though this is not a universal rule

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The dose conversion rate from IR- to ER-Tac has been calculated to +8% (138), possibly attributed to lower saturation of CYP3A and P-gp by a prolonged release in the intestine and therefore resulting in an increase of the metabolism rate ( de novo renal transplant recipients of 30%, as shown in a randomized controlled trial, the starting dose for LCP-Tac was reduced to 0.17 mg/kg/day (139)